Live Streaming Liputan6 Update, Rabu, 22 September 2021 mengangkat tema Jangan Lengah Kasus Covid-19 di Indonesia Melandai bersama Aditya Eka Prawira, Editor Health Liputan6.com dipandu Host Ratu Annisa. Selain itu ada laporan update mengenai dugaan korupsi lahan di Munjul, PTM ditunda karena 90 siswa terkena Covid-19, Pendaki hilang misterius di Gunung Guntur, dan laporan langsung dari Latvia, Eropa Timur saat Pandemi Covid-19.
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