Keraguan terhadap vaksin menjadi kendala bagi tercapainya kekebalan imunitas, yang menurut ahli medis memerlukan vaksinasi 70-90% warga setiap negara. Di AS, angkanya mencapai 26% berdasarkan survei lembaga Gallup, penurunan dibandingkan pertengahan 2020. Tenaga medis pun dipaksa melakukan inovasi.
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