COVID-19 memaksa penutupan sebagian besar kegiatan lintas batas AS-Meksiko, tapi sejumlah kota di perbatasan tetap membolehkan lalu-lalang manusia untuk kegiatan esensial. Kota seperti ini San Diego, California dan El Paso, Texas kegiatan ekonominya praktis menyatu dengan kota di seberang perbatasan
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